Pharmacokinetics of continuous intravenous and subcutaneous infusions of cytosine arabinoside.

نویسندگان

  • H J Weinstein
  • T W Griffin
  • J Feeney
  • H J Cohen
  • R D Propper
  • S E Sallan
چکیده

The pharmacokinetics of continuous subcutaneous cytosine arabinoside (ara-C) infusions were compared with continuous intravenous infusions. Steady-state serum ara-C levels and myelosuppression were similar with both routes of administration. CSF/serum ara-C ratios ranged from 0.14 to 0.91 (mean, 0.58). Continuous subcutaneous ara-C infusions were a convenient and reliable alternative to intravenous infusions.

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عنوان ژورنال:
  • Blood

دوره 59 6  شماره 

صفحات  -

تاریخ انتشار 1982